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  1. Cervical neoplasia in pap smears : risk of cervical intra-epithelial neoplasia (CIN) after negative or no prior smears in a population without a mass screening programme.

    Article - En anglais

    Background

    The aim of this study was to examine, in a population not submitted to mass screening, the risk of cancer and cervical intra-epithelial neoplasia (CIN) in Pap smears from women without previously reported positive smears.

    Methods

    In a logistic regression model consisting of 58 271 smears from 40 536 Norwegian women the risk of cytologically indicated CIN was studied according to age and time elapsed since last smear.

    Results

    The risk of CIN was highest in smears from women with no previously registered smears and in smears taken after an interval of =5 years.

    Odds ratio for CIN I-II adjusted for age was highest in first time smears and in smears taken after an interval of 5 years.

    Odds ratio for CIN III was highest in first registered smears.

    No difference in risk of CIN III was found in smears taken within one year or 2-3 years after the last smear.

    The increased risk of CIN III in first smears was most pronounced in postmenopausal women (>50 years).

    Nine of 16 cases with cytological indication of cancer were found in women having a smear taken for the first time.

    All cases with malignancy in smears were>50 years.

    Conclusions

    The risk of cytologically diagnosed premalignant cervical conditions increases with time since the previous smear, but more than 5 years have to elapse before the risk is comparable with that in first smears taken.

    Postmenopausal women without previous smears run the highest risk of serious cervical premalignancies and cancer.

    Mots-clés Pascal : Tumeur maligne, Col utérus, Frottis cervical, Exploration cytologique, Dépistage, Femme, Homme, Campagne de masse, Programme sanitaire, Age, Norvège, Europe, Risque, Utérus pathologie, Appareil génital femelle pathologie

    Mots-clés Pascal anglais : Malignant tumor, Uterine cervix, Cervical smear, Cytologic investigation, Medical screening, Woman, Human, Mass campaign, Sanitary program, Age, Norway, Europe, Risk, Uterine diseases, Female genital diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0123768

    Code Inist : 002B20C02. Création : 199608.