Increased variability in bronchial responsiveness in aluminum potroom workers with work-related asthma-like symptoms.
In a longitudinal study, we studied the variability in bronchial responsiveness (BR) to methacholine in aluminum potroom workers suffering from work-related asthma-like symptoms (WASTH) and in symptom-free workers.
In the index group, 26 men suffering from WASTH were selected from a cross-sectional survey.
The reference group comprised 45 symptom-free men recruited from the enrollment of new employees.
Bronchial responsiveness was expressed as the dose-response slope (DRS) of the line through origin and the last data point.
The standard deviation of the log-transformed DRS was positively associated with symptom score (P=012) and the mean BR (P<. 001).
Our results indicate that the severity of respiratory symptoms in aluminum potroom workers with WASTH reflects the variability in BR.
Mots-clés Pascal : Fonderie, Four pot, Aluminium, Exposition professionnelle, Homme, Test provocation, Toxicité, Médecine travail, Poumon pathologie, Appareil respiratoire pathologie, Asthme like
Mots-clés Pascal anglais : Foundry, Pot furnace, Aluminium, Occupational exposure, Human, Provocation test, Toxicity, Occupational medicine, Lung disease, Respiratory disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0122948
Code Inist : 002B03L05. Création : 199608.