To examine whether meat intake modifies breast-cancer risk, a case-control study was conducted in Uruguay.
Dietary patterns were assessed in detail (for cases, before diagnosis or symptoms occurred) using a food frequency questionnaire involving 64 food items, which allowed total energy intake to be calculated.
Nutrient residuals were calculated through regression analysis.
After adjustment for potential confounders (which included family history of breast cancer, menopausal status, body-mass index, total energy and total alcohol intake), an increased risk associated with consumption of total meat intake, red meat intake, total fat and saturated fat intake was observed.
The strongest effect was observed for red meat intake (OR 4.2,95% CL 2.3-7.7) for consumption in the upper quartile, after controlling for protein and fat intake.
This suggests an independent effect for meat.
Since experimental studies have shown a strong effect of heterocyclic amines in rat mammary carcinogenesis, further studies should be performed in human epidemiology, perhaps using biomarkers of heterocyclic amine exposure.
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Facteur risque, Epidémiologie, Viande, Matière grasse, Alimentation, Uruguay, Amérique du Sud, Amérique, Homme, Glande mammaire pathologie, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Risk factor, Epidemiology, Meat, Fat, Feeding, Uruguay, South America, America, Human, Mammary gland diseases, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0121371
Code Inist : 002B20E02. Création : 199608.