International neurotoxicology conference. Hot Springs AR USA, 1994/10/30.
Studies of outbreaks of methylmercury poisoning in Japan and Iraq from consumption of methylmercury (MeHg) - contaminated fish or bread proved that brain was the target organ, the toxic effects were dose-related, and the fetal brain was especially susceptible.
Previous population studies suggested that a 5% risk of minimal fetal effect may be associated with a maternal hair mercury concentration during pregnancy of 10-20 ppm (mug/g), a level that can be readily achieved by frequent consumers of fish.
However, these studies had limitations.
And as a result no definite conclusion concerning the lowest effect level could be reached and the question of a possible hazard to public health remained unanswered.
There was a clear need for a more definitive study that would be prospective, involve a large enough cohort for risk analysis and adhere to accepted epidemiological principles.
An appropriate site for such a study is the Republic of Seychelles, a location that afforded successful collaboration between the Seychelles Ministry of Health and faculty of the University of Rochester.
A pilot study of 804 infant-mother pairs was followed by a main study of 779 mother-infant pairs.
In the pilot study children were examined once between 5 and 109 weeks of age ; in the main study they are being evaluated longitudinally starting at 6 1/2 months of age.
This paper introduces both the pilot and main studies, describes their design, andsummarizes the findings through 6 1...
Mots-clés Pascal : Mercure, Métal lourd, Toxicité, Foetus, Système nerveux pathologie, Enfant, Homme, Développement postnatal, Développement embryonnaire, Contamination, Aliment, Poisson comestible, Epidémiologie, Seychelles, Iles Océan Indien, Mercure(méthyl)
Mots-clés Pascal anglais : Mercury, Heavy metal, Toxicity, Fetus, Nervous system diseases, Child, Human, Postnatal development, Embryonic development, Contamination, Food, Edible fish, Epidemiology, Seychelles, Indian Ocean Islands
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0119343
Code Inist : 002B03L05. Création : 199608.