In order to estimate the residual risk of transfusion-transmitted HCV infection, we have analyzed data from two transfusion centers in Austria (Vienna) and Germany (Göttingen) from 1990 to 1995.
In Vienna, the seroprevalence (RIBA-confirmed third-generation anti-HCV tests) was 0.28% in first-time donors (FTD) and the incidence of seroconversion in repeat donors (RD) was 0.049 (per 100 person years) from 1994 to 1995.
In Göttingen, the prevalence of a PCR-confirmed positive third-generation anti-HCV test was 0.22% in FTDs and the incidence was 0.093 (per 100 person years).
A continuous decline of the rate of anti-HCV-positive donations and donors was observed with first-and second-generation anti-HCV tests in the years 1990-1994.
The introduction of the third-generation anti-HCV test resulted in increased numbers of anti-HCV positive repeat donors, mainly due to false-positive results.
Only 9% of anti-HCV-positive repeat donors were either PCR positive or RIBA positive or indeterminate.
Based on a mathematical model which takes (a) the window period, (b) the false-negative rate of anti-HCV tests, and (c) human and operational errors into consideration, we have calculated the residual risk of HCV infection.
We used a window period of 74 days, a sensitivity of 98%, and an error rate of 0.1%. The residual risk (for third-generation anti-HCV test-negative blood components) was calculated to be 1 : 9000 (95% confidence interval 1 : 16390-1 : 621 (1) and 1 : 4800...
Mots-clés Pascal : Transfusion, Sang, Complication, Hépatite virale C, Virose, Infection, Virus hépatite C, Flaviviridae, Virus, Facteur risque, Incidence, Prévalence, Epidémiologie, Allemagne, Europe, Autriche, Donneur, Méthode immunoblotting, Réaction chaîne polymérase, Homme, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Transfusion, Blood, Complication, Viral hepatitis C, Viral disease, Infection, Hepatitis C virus, Flaviviridae, Virus, Risk factor, Incidence, Prevalence, Epidemiology, Germany, Europe, Austria, Donor, Immunoblotting assay, Polymerase chain reaction, Human, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0108959
Code Inist : 002B27D01. Création : 199608.