Objectives-Endothelin 1 (ET1) is one of a newly discovered family of potent naturally occurring vasoconstrictors produced by the endothelium.
A few publications indicated that the peptide may have a role in idiopathic Raynaud's phenomenon and Raynaud's phenomenon secondary to connective tissue disease.
The aim of this study was to compare serum endothelin concentrations in people with vibration induced white finger (VWF) with those of controls exposed to vibration, and unexposed (pure) controls.
Subjects and methods-Male volunteers from a stonemasonry, two quarries, and an insurance company were classified by questionnaire and clinical examination into men with VWF (cases, n=31), exposed controls (n=22), or pure controls (n=36).
All subjects were asked to provide two venous blood specimens : a baseline sample after a period of warm equilibration (30 minutes seated in a warm room and 20 minutes with both hands immersed in a water bath at 37°C) ; and again after cold challenge (both hands immersed in a water bath at 6°C for six minutes).
Serum concentrations of the 21 amino acid peptide endothelin ET1-21 were measured by radioimmunoassay.
Baseline concentrations of ET1-21 were found to be lower in cases (mean=12.2 pmol/l) than in the two control groups (mean=14.7 pmol/l in exposed controls ; mean=14.3 pmol/l in pure controls).
Among cases there was a broad inverse relation between severity, as measured by the Griffin blanching score, and baseline ET1...
Mots-clés Pascal : Raynaud syndrome, Trouble dû aux vibrations, Exposition professionnelle, Homme, Endothéline, Vasoconstricteur, Sérum, Long terme, Membre supérieur, Médecine travail, Physiopathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Capillaire sanguin pathologie, Peau pathologie, Système nerveux autonome pathologie, Acrosyndrome
Mots-clés Pascal anglais : Raynaud phenomenon, Vibration induced disorder, Occupational exposure, Human, Endothelin, Vasoconstrictor agent, Serum, Long term, Upper limb, Occupational medicine, Pathophysiology, Cardiovascular disease, Vascular disease, Capillary vessel disease, Skin disease, Diseases of the autonomic nervous system, Acrosyndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0108935
Code Inist : 002B12B03. Création : 199608.