To investigate the clinical, serological, and environmental features of a work related inhalational fever associated with exposure to an aerosol generated from a biologically contaminated 130 000 gallon water pool in a building used for testing scientific equipment.
Method-Cross sectional survey of all exposed subjects (n=83) by symptom questionnaire, clinical examination, spirometry, and serology for antibody to Pseudomonads, pool water extract, and endotoxin.
In symptomatic patients diffusion capacity was measured, and chest radiology was performed if this was abnormal.
Serial peak flow was recorded in those subjects with wheeze.
Bacterial and fungal air sampling was performed before and during operation of the water pool pump mechanism.
Endotoxin was measured in the trapped waters and in the pumps.
Serum cotinine was measured as an objective indicator of smoking.
Of the 20 symptomatic subjects, fever was most common in those with the highest exposure (khi2 42.7, P<0.001) in the sump bay when the water was (torrentially) recirculated by the water pumps.
Symptoms occurred late in the working day only on days when the water pumps were used, and were independent of the serum cotinine.
Pulmonary function was normal in most subjects (spirometry was normal in 79183, diffusion capacity was low in five subjects, chest radiology was normal).
Peak flow recording did not suggest a work relation.
The bacterial content of the aerosol rose from 6 to>...
Mots-clés Pascal : Aérosol, Origine microbienne, Puisard, Inhalation, Toxicité, Allergie, Appareil respiratoire pathologie, Fièvre, Qualité eau, Contamination biologique, Homme, Exposition professionnelle, Médecine travail, Immunopathologie
Mots-clés Pascal anglais : Aerosols, Microbial origin, Sump, Inhalation, Toxicity, Allergy, Respiratory disease, Fever, Water quality, Biological contamination, Human, Occupational exposure, Occupational medicine, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0108934
Code Inist : 002B06C02. Création : 199608.