Toxicokinetics of 2,4-and 2,6-toluenediamine in hydrolysed urine and plasma after occupational exposure to 2,4-and 2,6-toluene diisocyanate.
Objectives-To assess the toxicokinetics of 2,4-and 2,6-toluenediisocyanate (TDI) in chronically exposed subjects.
Methods-Blood and urine, from 11 workers at two flexible foam polyurethane production plants, were sampled.
By gas chromatography-mass spectrometry (GC-MS) 2,4-and 2,6-toluene diamine (TDA) were measured as pentafluoropropionic anhydride (PFPA) derivatives after acidic hydrolysis of plasma (P-TDA, ng/ml) and urine (U-TDA, mug/h).
In one of the plants the P-2,4-TDA concentrations were 0.4-1 ng/ml before a four to five week holiday and 0.2-0.5 ng/ml afterwards.
The corresponding values for P-2,6-TDA were 2-6 and 0.5-2 nglml respectively.
In the other plant the P-2,4-TDA concentrations were 2-23 ng/ml before the holiday and 0.5-6 ng/ml afterwards and the P-2,6-TDA concentrations were 7-24 ng/ml before and 3-6 ng/ml afterwards.
The P-2,4-TDA concentrations were 2-24 ng/ml before a 12 day holiday, and 1-14 ng/ml afterwards.
The corresponding values for P-2,6-TDA were 12-29 and 8-17 ng/ml, respectively.
The urinary elimination rates (U-TDA, mug/h) for 2,4-TDA before the holiday were 0.04-0.54 and 0.02-0.18 mug/h afterwards.
The corresponding values for 2,6-TDA were 0.18-0.76 mug/h before and 0.09-0.27 mug/h after the holiday.
The half life in urine ranged between 5.8 and 11 days for 2,4-and 2,6-TDA.
The differences in exposure were reflected by the P-TDA concentrations.
The mean half life in plasma was 21 (range 14-34) days for 2,4-TDA and 21...
Mots-clés Pascal : Toluène dérivé, Diisocyanate organique, Exposition professionnelle, Homme, Toxicocinétique, Urine, Plasma sanguin, Marqueur biologique, Long terme, Surveillance biologique, Alvéolaire, Inhalation, Médecine travail, Toluène(2,4-diisocyanato), Toluène(2,6-diisocyanato)
Mots-clés Pascal anglais : Toluene derivatives, Organic diisocyanate, Occupational exposure, Human, Toxicokinetics, Urine, Blood plasma, Biological marker, Long term, Biological monitoring, Foam(plastics), Inhalation, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0108932
Code Inist : 002B03L06. Création : 199608.