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  1. Maternal occupational exposure during pregnancy and the risk of spina bifida.

    Article - En anglais

    Objectives-A case-control study was carried out to explore associations between spina bifida and occupational exposure of the mother.

    Methods-The cases were children with spina bifida aperta born between 1980 and 1992 from nine hospitals in the Netherlands.

    The controls were children born healthy in the same period as the cases, from hospitals and from the general population.

    Data collection was carried out in two steps.

    Firstly, postal questionnaires were sent to all the parents of cases and controls to gather information on occupations and potential confounders.

    In the second phase of the study, information on specific exposures was collected by means of job and task specific personal interviews.

    Interviews were performed with 55 case mothers and 66 control mothers who had occupations with a potential for chemical or physical exposure.

    Those exposures were assumed to be negligible for-for example, teachers and secretaries, so personal interviews were not indicated for these women.

    Information was collected on specific tasks in the period just after conception, and on the associated use of chemical or physical agents, frequency of exposure, and use of protective equipment.


    The analyses of occupation showed an increased risk for women working in agricultural occupations (OR=3.4, CI : 1.3-9.0), and, although less distinct, for cleaning women (OR=1.7, CI : 0.9-3.4).

    Only a few women seemed to be occupationally exposed to chemical or physical agents. ...

    Mots-clés Pascal : Spina bifida, Enfant, Homme, Descendance, Toxicité, Exposition professionnelle, Mère, Gestation, Epidémiologie, Pays Bas, Europe, Médecine travail, Activité professionnelle, Système ostéoarticulaire pathologie, Rachis pathologie, Maladie congénitale, Malformation

    Mots-clés Pascal anglais : Spina bifida, Child, Human, Progeny, Toxicity, Occupational exposure, Mother, Pregnancy, Epidemiology, Netherlands, Europe, Occupational medicine, Professional activity, Diseases of the osteoarticular system, Spine disease, Congenital disease, Malformation

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0108930

    Code Inist : 002B17D. Création : 199608.