Morbillivirus infections. International symposium. Hannover DEU, 1994/06/12.
Despite an increase in global measles vaccine coverage from under 20% in 1980 to around 80% in 1990, measles remains a major cause of morbidity and mortality world-wide.
This paper addresses a number of issues relating to efforts to control measles, namely, (i) at the global level, how might we assess the impact of measles vaccination on the incidence of infection and associated disease, and, (ii), at the strategic level, how can we utilise an understanding of the transmission dynamics of childhood viral infections to aid the design of optimal immunisation programmes ?
Based on WHO vaccine coverage data, and organising countries according to similarities in demographic and epidemiological parameters, an age-structured model of measles transmission is used to capture the nonlinear dynamics of infection and mass vaccination and to generate projections of the impact of measles immunization world-wide.
The results provide a crude indication of the percentage reduction in measles cases by year 2000 (compared with no immunization) and suggest an approximately 70% reduction in cases over all ages, and 77% reduction in cases under 5 years (where there is the greatest risk of case fatality) ; these suggest that WHO targets for 1995 are unlikely to be achieved.
In the second part of the paper, examples are given to illustrate the usefulness of a modelling approach in evaluating measles immunization policy.
The introduction of MMR vaccine in the UK in 1988 has result...
Mots-clés Pascal : Virus rougeole, Morbillivirus, Paramyxoviridae, Virus, Rougeole, Virose, Infection, Homme, Eradication, Vaccination, Immunisation, Monde, Modèle mathématique, Etude impact, Lutte sanitaire, Prévention, Peau pathologie
Mots-clés Pascal anglais : Measles virus, Morbillivirus, Paramyxoviridae, Virus, Measles, Viral disease, Infection, Human, Eradication, Vaccination, Immunization, World, Mathematical model, Impact study, Sanitary control, Prevention, Skin disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0108130
Code Inist : 002B05C02B. Création : 199608.