Selenoprotein P concentration in plasma is an index of selenium status in selenium-deficient and selenium-supplemented Chinese subjects.
Experimental Biology 94. Meeting. Anaheim CA USA, 1994/04/26.
Selenoprotein P, a selenium-rich plasma protein, is an index of selenium status in rats.
Antibodies against human selenoprotein P were raised to study the protein and to develop a radioimmunoassay for it.
A single collection of plasma from a healthy person in the United States contained 1.84 mumol selenium/L and was defined as containing 1 Unit (U) selenoprotein P/L. Removal of selenoprotein P from the reference plasma by an antibody column indicated that 0.81 mumol selenium/L, or 44% of the plasma selenium, was present as selenoprotein P. Work by others had determined that glutathione peroxidase accounted for 12% of plasma selenium.
Stored plasma samples from selenium-deficient (Dechang County) and selenium-supplemented (Mianning County) populations in China were assayed for selenoprotein P. Boys aged 8-12 y had selenoprotein P concentrations of 0.10 ± 0.04 U/L (n=22) in Dechang and 0.39 ± 0.17 U/L (n=17) in Mianning.
Supplementation with 100 mug selenium as selenate per day for 14 d raised those levels to 0.51 ± 0.13 U/L in Dechang and to 0.76 ± 0.27 U/L in Mianning.
Similar results were obtained in men, and plasma selenium concentrations correlated with selenoprotein P concentrations.
A study comparing indices of selenium status was conducted in the two counties.
Selenoprotein P concentration in Dechang subjects (n=79) was 36% of that in Mianning subjects (n=117).
For plasma glutathione peroxidase activity the value was 54% ; for plasma selenium, 47% ; ...
Mots-clés Pascal : Chine, Asie, Homme, Etat nutritionnel, Sélénium, Indicateur nutritionnel, Sélénoprotéine, Diagnostic, Carence alimentaire, Oligoélément, Elément minéral, Nutrition, Alimentation, Sélénoprotéine P
Mots-clés Pascal anglais : China, Asia, Human, Nutritional status, Selenium, Nutritional indicator, Selenoprotein, Diagnosis, Nutritional deficiency, Trace element (nutrient), Inorganic element, Nutrition, Feeding
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Cote : 96-0107019
Code Inist : 002B29B. Création : 199608.