The association of cigarette smoking with the development of occlusive vascular disease is firmly established.
Unfavourable changes in a series of variables held independent risk factors for the development of vascular lesions (HDL-cholesterol, haematocrit, white blood cell count, fibrinogen and plasminogen activator inhibitor-1 (PAI-1)) are thought to be directly influenced by cigarette smoking.
However, the role played by the genotype in the effect of smoking on the above parameters has not been investigated.
To control the genotype, we studied the relationship between cigarette smoking and a series of cardiovascular risk factors in 27 monozygotic twin pairs (7 male and 20 female pairs, mean age ± SD : 47.4 ± 12.9 yrs) with a life-long discordance for smoking.
Smoking twins had a life-long dose of smoking (Brickman index) of 287.3 ± 241.5. Body mass index, blood pressure, haematocrit, haemoglobin and red blood cell counts, total cholesterol levels and the acute phase reactants alpha1-acid glycoprotein and C-reactive protein were similar in smokers and non-smokers.
Triglyceride was higher by 12.6% (9.5-35%, 95% confidence interval, p=0.02) and HDL-cholesterol lower by 7.5% (0.2-15%, p=0.04) in the smoking co-twins, who also had 8.4% (-0.2-17%, p=0.06) higher white blood cell counts and 4.1% (1.2-7%, p<0.01) larger mean platelet volume.
There was no significant difference in clottable fibrinogen (by two methods) or in the activity of plasminogen activator ...
Mots-clés Pascal : Cardiopathie coronaire, Facteur risque, Epidémiologie, Tabagisme, Jumeau monozygote, Génotype, Italie, Europe, Homme, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Coronary heart disease, Risk factor, Epidemiology, Tobacco smoking, Monozygotic twin, Genotype, Italy, Europe, Human, Cardiovascular disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0106931
Code Inist : 002B12A03. Création : 199608.