A difficult task faced by regulatory agencies is that of choosing, on the basis of limited data, which environmental problems to address.
This paper incorporates USEPA risk assessment methods into a quantitative approach for prioritizing locations, contaminants and media according to potential health risk.
USEPA has developed either a reference dose (a chronic dose without adverse effect) or slope factor (upper bound lifetime cancer risk per mg. kg-1. d-1) for many substances.
This work combines these'toxicological constants'with predetermined risk levels (either a 10-6 cancer risk or a chronic intake equal to the reference dose) and protective human exposure assumptions (e.g. 70-kg body mass, 30-year exposure, 2-1. d-1 drinking water ingestion, etc.) to produce risk-based concentrations for 596 contaminants in air, drinking water, edible fish and soil.
Because USEPA designed its methods to estimate upper bound risks, these risk-based concentrations are likely to be protective of human health.
Regulatory officials can use this information to calculate numerical ratios between measured environmental levels and risk-based concentrations.
These ratios serve as a surrogate for potential health impacts and can be used to prioritize problems for attention.
Ratio calculation and ranking can be automated for searches of computerized environmental databases.
Mots-clés Pascal : Polluant, Environnement, Composé chimique, Evaluation, Toxicité, Méthode étude, Organisme réglementation, Base donnée, Homme, Etats Unis, Amérique du Nord, Amérique, Relation dose réponse, Classification, Produit dangereux
Mots-clés Pascal anglais : Pollutant, Environment, Chemical compound, Evaluation, Toxicity, Investigation method, Regulatory institution, Database, Human, United States, North America, America, Dose activity relation, Classification, Dangerous product
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0102292
Code Inist : 002B03M01. Création : 199608.