Gender differences in local and systemic reactions to inactivated influenza vaccine, established by a meta-analysis of fourteen independent studies.
In order to determine whether there is a difference between genders in reported adverse reactions to inactivated influenza vaccine, a computerized database of serological studies was investigated.
A standardized questionnaire was used to evaluate vaccine reactogenicity.
A total of 1,800 vaccinees in 14 studies were analyzed separately for two age groups (<60 and = 60 years of age).
Females reported significantly more local reactions than males.
The pooled odds ratio for the outcome measure « any local reaction » was 0.32 (95% confidence interval, 0.26-0.40, significant) and 0.54 (95% CI, 0.41-0.70, significant) for young and elderly adults, respectively.
Similar results were obtained for the outcome measure « any systemic reaction. » Previous exposure to influenza or influenza vaccine had no influence on reactogenicity.
There were no gender differences in sero-responses.
In conclusion, gender should be regarded as a predictor of reported reactions to influenza vaccine in both young and elderly adults and should be addressed in future study designs.
Mots-clés Pascal : Grippe, Virose, Infection, Sexe, Influenzavirus, Orthomyxoviridae, Virus, Disséminé, Toxicité, Effet secondaire, Immunoprophylaxie, Vaccin, Prévention, Souche inactivée
Mots-clés Pascal anglais : Influenza, Viral disease, Infection, Sex, Influenzavirus, Orthomyxoviridae, Virus, Disseminated, Toxicity, Secondary effect, Immunoprophylaxis, Vaccine, Prevention, Inactivated strain
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0102165
Code Inist : 002B05C02C. Création : 199608.