N-acetyl-S- (1,2,2-trichlorovinyl) - L-cysteine and 2,2,2-trichloroethanol : two novel metabolites of tetrachloroethene in humans after occupational exposure.
The excretion of tetrachloroethene metabolites in urine was studied in occupationally exposed workers to identify and quantify metabolites formed by glutathione conjugation and by cytochrome P450 oxidation of tetrachloroethene in humans.
The glutathione conjugation pathway has been implicated in the chronic toxicity and possible tumorigenicity of tetrachloroethene to the kidney in rats.
The biosynthesis of S- (1,2,2-trichlorovinyl) glutathione and N-acetyl-S- (1,2,2-trichlorovinyl) - L-cysteine in humans had not been demonstrated.
In this study, we investigated the biotransformation of tetrachloroethene in humans occupationally exposed during dry cleaning.
Tetrachloroethene concentrations in the air of the dry cleaning shop were 50 ± 4 ppm ; two individuals were exposed for 8 hr daily and two individuals were exposed for 4 hr daily.
In urine samples collected from the individuals at the beginning and at the end of the work week, N-acetyl-S- (1,2,2-trichlorovinyl) - L-cysteine and 2,2,2-trichloroethanol as tetrachloroethene metabolites in humans were identified by GC/MS.
The concentrations of N-acetyl-S- (1,2,2-trichlorovinyl) - L-cysteine in the urine of the individuals were not significantly different at the start and at the end of the work week ; however, concentrations of both N-acetyl-S- (1,2,2-trichlorovinyl) - L-cysteine and 2,2,2-trichloro compounds (trichloroacetic acid and 2,2,2-trichloroethanol) as a marker for cytochrome P450-mediated metabolism...
Mots-clés Pascal : Ethylène(tétrachloro), Solvant, Exposition professionnelle, Médecine travail, Toxicocinétique, Homme, Toxicité, Rein, Métabolisme
Mots-clés Pascal anglais : Ethylene(tetrachloro), Solvent, Occupational exposure, Occupational medicine, Toxicokinetics, Human, Toxicity, Kidney, Metabolism
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0099532
Code Inist : 002B03L04. Création : 199608.