Endogenous and exogenous factors in carcinogenesis : limits to cancer prevention.
Organ-specific cancer incidence rates can vary dramatically between low-and high-incidence areas.
Such differences are due to (1) heritable susceptibility determinants, (2) risk factors associated with the environmental and local living conditions (e.g., viruses, pollution), and (3) personal life-style factors.
For organs showing large differences between cancer registries, exogenous factors might be most important, while for organs showing only small differences, endogenous and unavoidable factors are expected to be more important.
In this paper, a working hypothesis based on descriptive cancer epidemiology is presented to estimate, in a quantitative manner, the unavoidable contribution to the process of carcinogenesis and to discuss limitations to individual cancer prevention.
Cumulative cancer incidence rates for a 75-year period of life (CR74, in percent) were taken from IARC Scientific Publication No. 120 (1992).
For each organ, values were ranked in ascending order, and the ratio between high-rate and low-rate registries (90th percentile/10th percentile) was determined.
This measure of variability among registries differed strongly between organs.
Largest ratios were seen for organs with well-known exogenous risk factors, such as pharynx, lip, tongue, mouth, liver, esophagus, and melanoma in males, and lung, esophagus, gallbladder, liver, and bladder in females.
Small ratios were seen for rectum, brain, colon, and Hodgkin's disease in males, and brea...
Mots-clés Pascal : Tumeur maligne, Spécificité organe, Déterminisme génétique, Mode de vie, Environnement, Homme, Incidence, Endogène, Facteur risque, Prévention, Epidémiologie, Article synthèse
Mots-clés Pascal anglais : Malignant tumor, Organ specificity, Genetic inheritance, Life habit, Environment, Human, Incidence, Endogenous, Risk factor, Prevention, Epidemiology, Review
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0098892
Code Inist : 002B04B. Création : 199608.