We analysed the relationship between free 2,5-hexanedione (2,5-HD) and total 2,5-HD in the urine of 87 workers exposed to n-hexane and other solvents (hexane isomers, acetone and toluene), in relation to different working conditions.
The concentration of free 2,5-HD in urine of workers exposed to n-hexane was about 12% of total urinary 2,5-HD.
The most significant correlation (r=0.936) was that of total 2,5-HD in urine with environmental n-hexane and exhaled air.
With equal exposure to n-hexane, the concentrations in urine of free and total 2,5-HD increased when cutaneous absorption was involved (gloves not used), during the working week and with co-exposure to acetone.
An analysis of the relationship between combined exposure to acetone and urinary concentrations of the various forms of 2,5-HD suggests that acetone might influence the toxicokinetics of n-hexane, increasing the proportion of free 2,5-HD.
Mots-clés Pascal : Hexane, Solvant organique, Acétone, Association toxique, Exposition professionnelle, Hexane-2,5-dione, Surveillance biologique, Homme, Urine, Toxicocinétique, Absorption, Peau, Accumulation biologique, Médecine travail
Mots-clés Pascal anglais : Hexane, Organic solvent, Acetone, Toxic association, Occupational exposure, Biological monitoring, Human, Urine, Toxicokinetics, Absorption, Skin, Biological accumulation, Occupational medicine
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Cote : 96-0096906
Code Inist : 002B03L04. Création : 199608.