Synchronous variations of the incidence of temporal arteritis and polymyalgia rheumatica in different regions of Denmark ; association with epidemics of Mycoplasma pneumoniae infection.
The etiology of temporal arteritis (TA) and polymyalgia rheumatica (PMR) is unknown, but the sudden onset and the wide variation in incidence reported from various parts of the world suggest the existence of environmental and/or genetic factors.
We studied the incidence of TA and PMR during a 12 year period in different regions of Denmark.
For the period 1982 to 1994, data were obtained on the incidence of PMR and TA prospectively recorded in 2 general hospitals, and for 1982 to 1993 on the incidence reported by legal requirement to the national patient register by all hospitals in 13 of the 16 counties in Denmark.
In 2 counties data on all temporal artery biopsies were obtained.
Serological epidemiological surveillance data on infections causing epidemics in Denmark were obtained from the Statens Seruminstitut.
We analyzed data on 10,818 patients from 13 counties and 2651 temporal artery biopsies from two counties.
The incidence rate for TA for the population aged 50 years and older was 20.4/100,000 (95% Cl, 19-23), the rate for PMR was 41.3/100,000 (95% Cl, 30-67).
Significantly higher incidence rates were found in locations with high population density.
Median number of temporal artery biopsies performed was 109/100,000 population aged 50 years and older, and the number increased linearly with time : a positive biopsy result was observed in 15.0% ; the incidence rate of histologically proven TA in 2 counties was 15.1/100,000...
Mots-clés Pascal : Horton maladie, Pseudopolyarthrite rhizomélique, Incidence, Variation géographique, Danemark, Europe, Infection, Mycoplasma pneumoniae, Mycoplasmataceae, Mycoplasmatales, Mollicutes, Bactérie, Epidémie, Etiologie, Homme, Chronique, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Vascularite, Maladie système, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire
Mots-clés Pascal anglais : Giant cell arteritis, Polymyalgia rheumatica, Incidence, Geographical variation, Denmark, Europe, Infection, Mycoplasma pneumoniae, Mycoplasmataceae, Mycoplasmatales, Mollicutes, Bacteria, Epidemic, Etiology, Human, Chronic, Cardiovascular disease, Vascular disease, Vasculitis, Systemic disease, Diseases of the osteoarticular system, Inflammatory joint disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0094327
Code Inist : 002B07. Création : 199608.