We investigated any effect of prenatal exposure to influenza during gestation on subsequent risk of schizophrenia using a national sample from The Netherlands.
Dates of births of all Dutch-born schizophrenic (ICD-9) patients (n=10,630) admitted to hospitals for the first time between 1970 and 1992 were examined in relation to the occurrence of influenza epidemics between 1947 and 1969.
As a measure of prevalence of influenza, the number of deaths from influenza per month in The Netherlands was used.
A Poisson regression analysis revealed that an increase in the prevalence of influenza 3 months prior to birth was followed by an increase in births of preschizophrenics, although this fell outside statistical significance (p=11).
However, the effect became marked in typical schizophrenics (n=4726), but not in less typical cases (n=5389).
For typical schizophrenics, the parameter estimate derived from the regression model indicates that there was a 10% increase (95% confidence interval : - 1 to 22%) in preschizophrenic births for every 500 deaths from influenza 3 months before birth.
Mots-clés Pascal : Schizophrénie, Psychose, Date naissance, Gestation, Influenzavirus, Orthomyxoviridae, Virus, Mère, Facteur risque, Enquête, Epidémiologie, Pays Bas, Europe, Exposition, Prénatal, Etude cohorte, Adulte, Homme
Mots-clés Pascal anglais : Schizophrenia, Psychosis, Birth date, Pregnancy, Influenzavirus, Orthomyxoviridae, Virus, Mother, Risk factor, Inquiry, Epidemiology, Netherlands, Europe, Exposure, Prenatal, Cohort study, Adult, Human
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0094096
Code Inist : 002B18C06A. Création : 199608.