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  1. Second primary cancers in patients with cutaneous malignant melanoma : a population-based study in Sweden.

    Article - En anglais

    To quantify the risk of second primary cancers among patients with cutaneous malignant melanoma, we studied 20 354 patients in the Swedish Cancer Register during 1958-88.

    A second primary cancer was reported in 1605 patients, compared with an expected number of 1109.5 [standardised incidence ratio (SIR)=1.45,95% confidence interval (CI)=1.38-1.52]. The highest risk was found among patients younger than 60 years.

    The greatest risk was seen during the first year after diagnosis (SIR=1.91, CI=1.69-2.14), but even after long-term follow-up 15 years or more - the risk was still significantly elevated (SIR=1.56, CI=1.35-1.79).

    The strongest association was found for a second primary malignant melanoma (men, SIR=10.0, CI=8.26-12.00 ; women, SIR=8.66, CI=7.22-10.30) and non-melanoma skin cancer (men, SIR=3.58, CI=2.85-4.44 ; women, SIR=2.41, CI=1.71-3.29).

    The risk of second cancers associated with tissues of neuroectodermal origin was increased, especially tumours of the nervous system (men, SIR=1.73, CI=1.10-2.60 ; women, SIR=2.03, CI=1.45-2.78).

    The SIR of second cancers involving the immune system was also increased.

    An excess risk of endometrial cancer was seen (SIR=1.41, CI=1.03-1.88), but no significant associations existed for cancers of the breast, ovary, testis or other endocrine glands.

    Among tumours of the digestive tract, only colon cancer in men had a significantly increased SIR (1.33, CI=1.00-1.74).

    Mots-clés Pascal : Mélanome, Peau, Facteur risque, Epidémiologie, Second cancer, Méthode statistique, Suède, Europe, Homme, Tumeur maligne, Peau pathologie

    Mots-clés Pascal anglais : Melanoma, Skin, Risk factor, Epidemiology, Second cancer, Statistical method, Sweden, Europe, Human, Malignant tumor, Skin disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0088986

    Code Inist : 002B08A. Création : 199608.