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  1. Fulltext. Negative bias in exposure-response trends in occupational studies : modeling the healthy worker survivor effect.

    Article - En anglais


    Many occupational studies analyze trends between cumulative exposure and mortality.

    The authors show that such trends are, in general, negatively confounded by employment status.

    Mortality rates for workers who leave work ( « inactive » workers) are higher than for active workers because some workers leave because they are ill.

    The percentage of inactive relative to active person-time is higher in low categories of cumulative exposure, causing employment status to act as a negative confounder of exposure-response trends (the opposite occurs for time-since-hire).

    We illustrate these phenomena using 10 « negative » mortality studies, in which adjustment for employment status removes false trends.

    However, adjustment for employment status will lead to biased estimates when it acts as an intermediate variable between cumulative exposure and death, as occurs directly when exposure causes a disabling disease that, in turn, causes death or indirectly when exposure causes workers to leave work.

    The authors illustrate this problem using simulated follow-up data for leaving, disease incidence, and mortality.

    In the null case in which cumulative exposure affects neither disease incidence (or mortality) nor leaving rates, employment status indeed acts as a negative confounder of exposure-response trends, and traditional adjustment eliminates this confounding.

    However, when cumulative exposure affects disease incidence or rates of leaving, adjustment for employment status w...

    Mots-clés Pascal : Condition travail, Adaptation, Poste travail, Médecine travail, Mortalité, Epidémiologie, Biais méthodologique, Etude cohorte, Modèle mathématique, Activité professionnelle, Effet du travailleur en bonne santé

    Mots-clés Pascal anglais : Working condition, Adaptation, Workplace layout, Occupational medicine, Mortality, Epidemiology, Methodological bias, Cohort study, Mathematical model, Professional activity

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0086505

    Code Inist : 002B30B04. Création : 199608.