The associations of serum total and high density lipoprotein (HDL) cholesterol with coronary heart disease were investigated in men aged 64-84 years from the Dutch town of Zutphen during 5 years of follow-up.
In 1985,885 randomly selected men, 710 of whom did not have a history of clinical coronary heart disease, participated in the study.
Associations were adjusted for age, body mass index, systolic blood pressure, cigarette smoking, and alcohol consumption.
Total cholesterol was not significantly associated with the incidence of coronary heart disease, but for mortality the relative risk corresponding to a 1.00 mmol/liter increase was 1.40 (95 percent confidence interval (CI) 1.07-1.83).
HDL cholesterol was not associated with mortality from coronary heart disease.
The relative risk for the incidence of the disease, corresponding to a 0.26 mmol/liter increase, was 0.80 (95 percent Cl 0.60-1.08).
For the ratio of HDL cholesterol to total cholesterol, the relative risk for coronary heart disease incidence corresponding to a 0.05 increase amounted to 0.70 (95 percent Cl 0.51-0.95).
These results show that in elderly men followed for 5 years, both total and HDL cholesterol are important in predicting coronary heart disease.
Total cholesterol seems to be a stronger risk factor for mortality from the disease, whereas HDL cholesterol is more strongly associated with the incidence of a first coronary heart disease event.
Mots-clés Pascal : Cardiopathie coronaire, Epidémiologie, Facteur risque, Vieillard, Homme, Cholestérol HDL, Lipoprotéine, Cholestérol, Etude longitudinale, Pays Bas, Europe, Mortalité, Prospective, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Coronary heart disease, Epidemiology, Risk factor, Elderly, Human, Cholesterol HDL, Lipoprotein, Cholesterol, Follow up study, Netherlands, Europe, Mortality, Prospective, Cardiovascular disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0086500
Code Inist : 002B12A03. Création : 199608.