Blood antioxidant enzymes as markers of exposure or effect in coal miners.
To investigate if blood Cu+/Zn+superoxide dismutase, glutathione peroxidase, catalase, and total plasma antioxidant activities could be markers of biological activity resulting from exposure to respirable coal mine dust in active miners, and of pneumoconiosis in retired miners.
Methods-Blood samples were randomly obtained from active surface workers (n=30) and underground miners (n=34), and from retired miners without (n=21), and with (n=33) pneumoconiosis.
Antioxidant enzyme activities and total plasma antioxidants were measured in erythrocytes and plasma.
Non-parametric tests were completed by analyses of covariance to compare antioxidants between groups, taking into account potential confounding factors (age, smoking history (pack-years)). Results-Erythrocyte Cu+/Zn+superoxide dismutase activity was significantly higher in the group of underground miners than the group of surface workers.
The differences in total plasma antioxidants and plasma glutathione peroxidase activity between both groups were related to age.
Glutathione peroxidase activity increased in the plasma of retired miners with pneumoconiosis, compared with retired miners without pneumoconiosis.
No differences were found either in erythrocyte antioxidant enzyme activities or in total plasma antioxidants between the groups of retired miners without and with pneumoconiosis.
Conclusions-In this study, erythrocyte Cu+/Zn+superoxide dismutase activity may be considered as a marker of...
Mots-clés Pascal : Mine, Charbon, Exposition professionnelle, Homme, Médecine travail, Poussière, Surveillance biologique, Pneumoconiose, Marqueur biologique, Activité enzymatique, Superoxide dismutase, Oxidoreductases, Enzyme, Catalase, Peroxidases, Sang, Liquide biologique, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Mine, Coal, Occupational exposure, Human, Occupational medicine, Dust, Biological monitoring, Pneumoconiosis, Biological marker, Enzymatic activity, Superoxide dismutase, Oxidoreductases, Enzyme, Catalase, Peroxidases, Blood, Biological fluid, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0084370
Code Inist : 002B03L03. Création : 199608.