Susceptibility to multiple basal cell carcinomas : significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender.
The factors that determine development of single and multiple primary cutaneous basal cell carcinomas (BCCs) are unclear.
We describe a case-control study firstly, to examine the influence of allelism at the glutathione S-transferase GSTM1 and GSTT1 and cytochrome P450 CYP2D6 loci on susceptibility to these tumours and, secondly, to identify interactions between genotypes and relevant individual characteristics, such as skin type and gender.
Frequency distributions for GSTM1 genotypes in cases and controls were not different, although the frequency of GSTM1 A/B was significantly lower (P=0.048) in the multiple BCCs than in controls.
We found no significant differences in the frequencies of GSTTI and CYP2D6 genotypes in cases and controls.
Interactions between genotypes were studied by comparing multinomial frequency distributions in mutually exclusive groups.
These identified no differences between cases and controls for combinations of the putatively high risk GSTM1 null.
GSTTI null, CYP2D6 EM genotypes.
Interactions between GSTM1 A/B and the CYP2D6 PM and GSTT1-positive genotypes were also not different.
Frequency distributions of GSTM1 A/B with CYP2D6 EM in controls and multiple BCCs were significantly different (P=0.033).
The proportion of males in the multiple BCC group (61.3%) was greater than in controls (47.0%) and single BCC (52.2%), and the frequency of the combination GSTM1 null/male gender was significantly greater in patients with multiple tum...
Mots-clés Pascal : Carcinome basocellulaire, Glutathione transferase, Transferases, Enzyme, Cytochrome P450, Facteur risque, Allélisme, Génotype, Type, Peau, Sexe, Prédisposition, Epidémiologie, Angleterre, Grande Bretagne, Royaume Uni, Europe, Homme, Peau pathologie, Tumeur maligne, Etude cas témoin
Mots-clés Pascal anglais : Basal cell carcinoma, Glutathione transferase, Transferases, Enzyme, Cytochrome P450, Risk factor, Allelism, Genotype, Type, Skin, Sex, Predisposition, Epidemiology, England, Great Britain, United Kingdom, Europe, Human, Skin disease, Malignant tumor, Case control study
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0084300
Code Inist : 002B08A. Création : 199608.