Effects of exposure to lead on selected biochemical and haematological variables.
Blood and urine samples were taken from 34 persons occupationally exposed to lead and from 56 non-exposed control persons and blood lead and haemoglobin concentrations, red blood cell count, erythrocyte glutathione peroxidase (GSH-peroxidase) and acetylcholinesterase (AChE), and urinary delta-aminolevulinic acid were determined.
Blood lead concentrations of the lead-exposed subjects were within the range generally accepted as safe for occupationally-exposed adults in many countries (i.e. below 50 mug Pb/dl blood).
Yet, significant dose-dependent elevations were found in erythrocyte GSH-peroxidase and urinary delta-aminolevulinic acid.
The urinary delta-aminolevulinic acid concentration of lead-exposed smokers was significantly elevated over that of lead-exposed non-smokers.
Smoking did not affect the urinary delta-aminole-vulinic acid concentration of control persons.
In addition, a statistically significantly lower red blood cell count was observed in the lead-exposed group.
Our results indicate that the above described safety standard for blood lead concentrations in occupationally exposed adults, although generally accepted, needs revision.
Mots-clés Pascal : Plomb, Métal lourd, Exposition professionnelle, Homme, Médecine travail, Surveillance biologique, Biologie clinique, Constante biologique, Biochimie, Hématologie, Urine, Sang, Liquide biologique, Marqueur biologique, Toxicité, Activité enzymatique
Mots-clés Pascal anglais : Lead, Heavy metal, Occupational exposure, Human, Occupational medicine, Biological monitoring, Clinical biology, Biological constant, Biochemistry, Hematology, Urine, Blood, Biological fluid, Biological marker, Toxicity, Enzymatic activity
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0084241
Code Inist : 002B03L05. Création : 199608.