Several investigators have reported Hispanics to be at elevated risk for neural tube defects (anencephaly and spina bifida).
Factors contributing to this risk have not been established.
The authors conducted a case-control study of neural tube defects (NTDs) among births occurring in Harris County, Texas, from April 1,1989, through December 31,1991.
Through the use of multiple ascertainment methods, 59 cases of anencephaly and 32 cases of spina bifida were detected.
Controls (n=451) were sampled for the same time period from Harris County vital records.
Regardless of how Hispanic ethnicity was classified, having a Hispanic parent was a risk factor for both anencephaly and spina bifida.
The primary etiologic question was whether increased NTD risk in Hispanics is explained by maternal diabetes or by other factors (e.g., maternal birthplace, prenatal care, reproductive history, age, socioeconomic status).
Mexico-born Hispanics were no more likely than Texas-born Hispanics to deliver a fetus or infant with an NTD.
Having a Hispanic mother was a risk factor for anencephaly among infants born to women with early prenatal care (odds ratio (OR)=4.54,95% confidence interval (Cl) 2.21-9.40) but not for those born to latecomers.
Earlier prenatal care seemed « protective » for non-Hispanics (OR=0.18,95% Cl 0.06-0.65) but not for Hispanics.
After simultaneous adjustment for eight variables in multivariate analysis, having a Hispanic (versus non-Hispanic) mother remained...
Mots-clés Pascal : Tube neural, Spina bifida, Anencéphalie, Nourrisson, Homme, Epidémiologie, Facteur risque, Ethnie, Texas, Etats Unis, Amérique du Nord, Amérique, Système ostéoarticulaire pathologie, Rachis pathologie, Maladie congénitale, Malformation, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Hispanique
Mots-clés Pascal anglais : Neural tube, Spina bifida, Anencephaly, Infant, Human, Epidemiology, Risk factor, Ethnic group, Texas, United States, North America, America, Diseases of the osteoarticular system, Spine disease, Congenital disease, Malformation, Nervous system diseases, Central nervous system disease, Cerebral disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0079228
Code Inist : 002B17D. Création : 199608.