Background The toxicity of styrene on the peripheral nervous system is still debated.
Cases The paper presents two cases of peripheral sensorimotor neuropathy in styrene-exposed workers.
Exposure, evaluated by biological monitoring, ranged between 100 and 150% of the current limits proposed by the American Conference of Governmental Industrial Hygienists (ACGIH).
The subjects complained of leg weakness and numbness, cramps, and paresthesia.
Electrophysiology revealed a moderate peripheral sensorimotor neuropathy of a demyelinating type.
Color-vision testing showed a subclinical deficit.
Common inherited and acquired causes of peripheral neuropathy and dyschromatopsia other than styrene were ruled out by personal history, medical examination, laboratory data, and chest X-ray.
Conclusions The results suggest that long-term occupational exposure to environmental levels of styrene that are equal, or slightly above, the ACGIH limits can induce a clinical form of peripheral neuropathy and a subclinical impairment of color vision.
As a consequence, a careful reappraisal of the real preventive meaning of the current ACGIH occupational limit for styrene, at least on an individual basis, is needed.
Mots-clés Pascal : Styrène, Toxicité, Exposition professionnelle, Neuropathie périphérique, Homme, Vision couleur, Trouble vision, Concentration maximale admissible, Surveillance biologique, Médecine travail, Etude cas, Système nerveux pathologie, Nerf périphérique pathologie
Mots-clés Pascal anglais : Styrene, Toxicity, Occupational exposure, Peripheral neuropathy, Human, Color vision, Vision disorder, Maximum permissible concentration, Biological monitoring, Occupational medicine, Case study, Nervous system diseases, Peripheral nerve disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0075309
Code Inist : 002B03L06. Création : 199608.