To evaluate the feasibility of intraarterial infusion of microencapsulated anticancer drugs (chemoembolization), collective data on 1013 cancer patients were reviewed.
Ethylcellulose microcapsules containing mitomycin C (median total dose 20 mg), cisplatin (60 mg) or peplomycin (40 mg) were given to tumor-feeding arteries by bolus infusion in 79% of the patients and by fractionated infusion in the others, as a palliative (71%) or preoperative measure (29%). The target sites were the liver (42%), kidney (24%), intrapelvic organs (18%), lung (4%), head and neck (3%), bone (1%) and others (9%), excluding the central nervous system and gastrointestinal tract.
The incidence of overall adverse effects ranged from 0.2 to 54.9%, but grade 2-3 hematological, renal and hepatic toxicities, local pain, abdominal discomfort, cutaneous reaction, remote embolization and infection were<10%. Nine patients (0.9%) in the early stages of trials suffered serious complications including treatment-related death in two with critical underlying diseases of the target organs.
The remaining patients recovered from the adverse effects, except for grade 2 cutaneous reactions, within 2 months by routine palliative measures.
A =50% tumor reduction was seen in 28% of 427 evaluable tumors (42% for<25-cm2 tumors and 20% for =25-cm2 tumors) with a median treatment number of one.
The response rate depended on both the tumor size and the treatment number (P<0.05), but it was not affected by p...
Mots-clés Pascal : Mitomycine, Cisplatine, Péplomycine, Anticancéreux, Ciblage, Tumeur maligne, Microcapsule, Voie intraartérielle, Voie locale, Embolisation, Chimiothérapie, Traitement, Soin palliatif, Préopératoire, Toxicité, Homme, Cathéter, Etude générale, Antibiotique, Platine II Complexe, Epidémiologie, Japon, Asie, traitement régional
Mots-clés Pascal anglais : Antineoplastic agent, Targeting, Malignant tumor, Microcapsule, Intraarterial administration, Local administration, Embolization, Chemotherapy, Treatment, Palliative care, Preoperative, Toxicity, Human, Catheter, General study, Antibiotic, Platinum II Complexes, Epidemiology, Japan, Asia, Regional treatment
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0074981
Code Inist : 002B02R02. Création : 199608.