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  1. Targeted cancer chemotherapy with arterial microcapsule chemoembolization : review of 1013 patients.

    Article - En anglais

    To evaluate the feasibility of intraarterial infusion of microencapsulated anticancer drugs (chemoembolization), collective data on 1013 cancer patients were reviewed.

    Ethylcellulose microcapsules containing mitomycin C (median total dose 20 mg), cisplatin (60 mg) or peplomycin (40 mg) were given to tumor-feeding arteries by bolus infusion in 79% of the patients and by fractionated infusion in the others, as a palliative (71%) or preoperative measure (29%). The target sites were the liver (42%), kidney (24%), intrapelvic organs (18%), lung (4%), head and neck (3%), bone (1%) and others (9%), excluding the central nervous system and gastrointestinal tract.

    The incidence of overall adverse effects ranged from 0.2 to 54.9%, but grade 2-3 hematological, renal and hepatic toxicities, local pain, abdominal discomfort, cutaneous reaction, remote embolization and infection were<10%. Nine patients (0.9%) in the early stages of trials suffered serious complications including treatment-related death in two with critical underlying diseases of the target organs.

    The remaining patients recovered from the adverse effects, except for grade 2 cutaneous reactions, within 2 months by routine palliative measures.

    A =50% tumor reduction was seen in 28% of 427 evaluable tumors (42% for<25-cm2 tumors and 20% for =25-cm2 tumors) with a median treatment number of one.

    The response rate depended on both the tumor size and the treatment number (P<0.05), but it was not affected by p...

    Mots-clés Pascal : Mitomycine, Cisplatine, Péplomycine, Anticancéreux, Ciblage, Tumeur maligne, Microcapsule, Voie intraartérielle, Voie locale, Embolisation, Chimiothérapie, Traitement, Soin palliatif, Préopératoire, Toxicité, Homme, Cathéter, Etude générale, Antibiotique, Platine II Complexe, Epidémiologie, Japon, Asie, traitement régional

    Mots-clés Pascal anglais : Antineoplastic agent, Targeting, Malignant tumor, Microcapsule, Intraarterial administration, Local administration, Embolization, Chemotherapy, Treatment, Palliative care, Preoperative, Toxicity, Human, Catheter, General study, Antibiotic, Platinum II Complexes, Epidemiology, Japan, Asia, Regional treatment

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0074981

    Code Inist : 002B02R02. Création : 199608.