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  1. Antimicrobial resistance and prevalence of extended spectrum bêta-lactamase among clinical isolates of Gram-negative bacteria in Riyadh.

    Article - En anglais

    The activity of ciprofloxacin, imipenem and 12 other commonly used antibiotics was evaluated against 106 documented clinical isolates from a medical Intensive Care Unit (ICU).

    The resistance rates to ceftriaxone, cefotaxime, aztreonam and ceftazidime were 42,25,24 and 21%, respectively.

    Apart from Pseudomonas aeruginosa, all isolates were sensitive to ciprofloxacin and imipenem.

    Complete cross resistance among tested bêta-lactam groups was uniformly evident in Enterobacter cloacae, Citrobacter freundii and P. aeruginosa.

    On the other hand, penicillins and second generation cephalosporins showed cross resistance among Escherichia coli and Klebseilla pneumoniae isolates.

    Induction experiments indicate that 70 and 62% of P. aeruginosa and E. cloacae or C. freundii produce class I cephalosporinase, respectively.

    Among all tested isolates, plasmid mediated extended spectrum bêta-lactamase (ESBL) was detected in one isolate of K pneumoniae.

    The plasmid mediated bêta-lactamase is transferable and inhibited by bêta-lactamase inhibitors.

    The transconjugates not only expressed resistance to extended spectrum bêta-lactams and aztreonam but also toward tested aminoglycoside antibiotics, with the exception of gentamicin.

    The obtained transconjugates conferred high level resistance to ceftazidime and aztreonam but considerably low resistance to ceftriaxone and cefotaxime.

    The isoelectric point for the extended-spectrum bêta-lactamase is 8.2.

    Mots-clés Pascal : Antibiotique, Antibactérien, Résistance, Isolat clinique, Homme, Unité soin intensif, Bactérie Gram négatif, In vitro, Arabie Saoudite, Asie, Infection nosocomiale, Hôpital, bêta-Lactamase, Hydrolases, Enzyme

    Mots-clés Pascal anglais : Antibiotic, Antibacterial agent, Resistance, Clinical isolate, Human, Intensive care unit, Gram negative bacteria, In vitro, Saudi Arabia, Asia, Nosocomial infection, Hospital, bêta-Lactamase, Hydrolases, Enzyme

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0074670

    Code Inist : 002B02S02. Création : 199608.