Intake of carotenoids and retinol in relation to risk of prostate cancer.
Several human studies have observed a direct association between retinol (vitamin A) intake and risk of prostate cancer ; other studies have found either an inverse association or no association of intake of bêta-carotene (the major provitamin A) with risk of prostate cancer.
Data regarding carotenoids other than bêta-carotene in relation to prostate cancer risk are sparse.
We conducted a prospective cohort study to examine the relationship between the intake of various carotenoids, retinol, fruits, and vegetables and the risk of prostate cancer.
Using responses to a validated, semiquantitative food-frequency questionnaire mailed to participants in the Health Professionals Follow-up Study in 1986, we assessed dietary intake for a 1-year period for a cohort of 47 894 eligible subjects initially free of diagnosed cancer.
Follow-up questionnaires were sent to the entire cohort in 1988,1990, and 1992.
We calculated the relative risk (RR) for each of the upper categories of intake of a specific food or nutrient by dividing the incidence rate of prostate cancer among men in each of these categories by the rate among men in the lowest intake level.
All P values resulted from two-sided tests.
Between 1986 and 1992,812 new cases of prostate cancer, including 773 non-stage Al cases, were documented.
Intakes of the carotenoids bêta-carotene, alpha-carotene, lutein, and bêta-cryptoxanthin were not associated with risk of non-...
Mots-clés Pascal : Adénocarcinome, Prostate, Homme, Epidémiologie, Facteur risque, Régime alimentaire, Rétinol, Caroténoïde, Etude cohorte, Etude longitudinale, Tumeur maligne, Appareil urinaire pathologie, Appareil génital mâle pathologie, Prostate pathologie, Vitamine
Mots-clés Pascal anglais : Adenocarcinoma, Prostate, Human, Epidemiology, Risk factor, Diet, Retinol, Carotenoid, Cohort study, Follow up study, Malignant tumor, Urinary system disease, Male genital diseases, Prostate disease, Vitamin
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0073891
Code Inist : 002B14D02. Création : 199608.