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  1. On individual and population effectiveness of vaccination.

    Article - En anglais

    Background

    The protective effect of a vaccine following an outbreak is often measured by the vaccine efficacy statistic, namely one minus the ratio of attack rates in vaccinees and non-vaccinees.

    This quantity is not an adequate measure of the population-level benefits of the vaccine.

    Methods

    We discuss two measures of the effectiveness of a vaccination programme.

    The first is the commonly used vaccine efficacy statistic.

    This is called here the individual vaccination effectiveness.

    The second measure, called the population effectiveness, is defined as one minus the ratio of the overall (or average) attack rate in the population when the vaccination programme is implemented to the expected attack rate in the same population without vaccination.

    We outline a method for computing the population effectiveness following an outbreak of a directly transmitted acute infectious disease in a closed heterogeneous population.

    We then explore and compare the behaviour of the two measures of vaccination effectiveness under various conditions.

    Results

    The population vaccination effectiveness is more robust than individual effectiveness to factors that may interfere with the evaluation of the performance of vaccination.

    Such factors are non-uniform vaccination, changes in contact patterns by vaccinees, and the ability of the vaccine to reduce infectiousness.

    Conclusion

    The population vaccination effectiveness is a more adequate measure of the population-level benefit...

    Mots-clés Pascal : Vaccination, Prévention, Efficacité, Programme sanitaire, Evaluation, Méthode mesure, Etude comparative, Homme

    Mots-clés Pascal anglais : Vaccination, Prevention, Efficiency, Sanitary program, Evaluation, Measurement method, Comparative study, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0072585

    Code Inist : 002B30A01C. Création : 199608.