logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Fulltext. Macromolecular adducts caused by environmental chemicals.

    Article, Communication - En anglais

    Fulltext.

    Arnold O. Beckman/IFCC European conference on environmental toxicology. Cannes FRA, 1995/06/01.

    We describe three biomonitoring studies in which hemoglobin (Hb) adducts were used as biochemical markers to assess indirectly the target dose of genotoxic chemicals.

    We monitored the exposure to 1,3-butadiene in occupationally exposed workers and in two control groups by analyzing the adducts formed by the reaction of the first activation product, butadiene monoepoxide, with the terminal valine of Hb ; we also measured hydrolyzable adducts formed by the reaction of metabolically formed nitroso derivatives with Hb from five selected nitropoly-cyclic aromatic hydrocarbons (1-nitropyrene, 2-nitrofluorene, 3-nitrofluoranthrene, 6-nitrochrysene, and 9-nitrophenanthrene) in coke oven workers of different job categories and control workers of the same geographical area.

    We detected hydrolyzable adducts from monocyclic nitroarenes in blood from individuals living in a contaminated area where explosives had been produced and from controls.

    The contaminants considered were 2,4,6-trinitrotoluene ; 2,4-and 2,6-dinitrotoluene ; and 1,3-dinitrobenzene.

    Differences between groups were significant, but interindividual variation was great and background exposures must be considered.

    Mots-clés Pascal : Polluant, Environnement, Toxicité, Carcinogène, Surveillance biologique, Exposition professionnelle, Homme, Médecine travail, Marqueur biologique, Arène, Composé nitro, Butadiène, Adduit moléculaire, Hémoglobine

    Mots-clés Pascal anglais : Pollutant, Environment, Toxicity, Carcinogen, Biological monitoring, Occupational exposure, Human, Occupational medicine, Biological marker, Arene, Nitro compound, Butadiene, Molecular adduct, Hemoglobin

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0071714

    Code Inist : 002B03M01. Création : 199608.