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  1. Fulltext. Significance of individual sensitivity to chemicals : elucidation of host susceptibility by use of biomarkers in environmental health research.

    Article, Communication - En anglais


    Arnold O. Beckman/IFCC European conference on environmental toxicology. Cannes FRA, 1995/06/01.

    Biomarker research has become the predominant theme for study of human dose-host-response relations to environmental chemicals.

    Increasing interest has been focused on identifying markers for host susceptibility, with mixed results.

    Efforts to identify markers for host variability in carcinogenic risk, on the basis of theoretical knowledge of carcinogen metabolism, have been disappointing.

    New work in the area of acquired risk modifiers, such as nutritional status, is theoretically attractive, but results have been limited.

    Impressive achievements have been made in the area of immunological variability, which may elucidate the molecular basis of as well as provide practical biomarkers for several diseases.

    The problem of multiple chemical sensitivities, on the other hand, has proved refractory to biomarker research, reflecting inadequate knowledge of the mechanism and inappropriate application of biomarker methods.

    Mots-clés Pascal : Composé chimique, Polluant, Environnement, Toxicité, Homme, Evaluation, Risque, Relation dose réponse, Prédisposition, Génétique, Carcinogène, Epidémiologie moléculaire, Marqueur biologique

    Mots-clés Pascal anglais : Chemical compound, Pollutant, Environment, Toxicity, Human, Evaluation, Risk, Dose activity relation, Predisposition, Genetics, Carcinogen, Molecular epidemiology, Biological marker

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0071711

    Code Inist : 002B03M01. Création : 199608.