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  1. Fulltext. Biomarkers as tools in human health risk assessment.

    Article, Communication - En anglais


    Arnold O. Beckman/IFCC European conference on environmental toxicology. Cannes FRA, 1995/06/01.

    Evaluation of occupational or environmental risk due to exposure to chemicals requires sufficient information on the toxic profiles, mechanisms of action, toxicokinetics, dose-response relation, exposure, and the target dose.

    Usually exposure is estimated by measuring concentrations of the agent in air, food, water, soil, dust, or other media with which a population or an individual is in contact.

    However, this external exposure is only a rough estimate for the internal exposure (agent dose or its metabolite at the critical target in the organism).

    Factors of influence are bioavailability of the chemicals, variations in concentrations and routes of exposure, physical activity, and individual variation in rates of metabolism, distribution, and excretion.

    All these affect the concentration of the toxic agent at the critical target, which is the most precise information for risk assessment.

    Thus, internal exposure is best measured by determining the concentration of the toxicant or its ultimate metabolite at the critical site in the target organ or by determining adducts with cellular macromolecules such as proteins, amino acids, DNA, or its bases.

    The latter are easily available in experimental toxicology from animal experiments but only occasionally from humans.

    For health surveillance such data usually are not available, because they require invasive procedures such as biopsies.

    Therefore, more accessible body fluids or tissue are used, such as blood, urin...

    Mots-clés Pascal : Composé chimique, Polluant, Environnement, Exposition professionnelle, Homme, Toxicité, Evaluation, Risque, Carcinogène, Marqueur biologique, Postmarquage, DNA, Adduit moléculaire

    Mots-clés Pascal anglais : Chemical compound, Pollutant, Environment, Occupational exposure, Human, Toxicity, Evaluation, Risk, Carcinogen, Biological marker, Postlabeling, DNA, Molecular adduct

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0071710

    Code Inist : 002B30A01A1. Création : 199608.