The authors investigated the risk of developing dementia for persons aged 50-75 years who suffered from Parkinson's disease, epilepsy, or severe head trauma.
They compared the risk in this patient group with the risk in a reference group in a follow-up study based on the linked databases of three Dutch nationwide morbidity registers over the years 1980-1989.
The overall relative risk of developing dementia within 8 years in patients with Parkinson's disease who were initially free of dementia was 3.0 (95% confidence interval (CI) 2.9-3.1).
Risk was especially increased in younger Parkinson's disease patients (relative risk (RR)=13.2,95% CI 6.2-28.6).
For patients with epilepsy, the overall relative risk was 1.5 (95% CI 1.4-1.7).
Severe head trauma was not associated with an increased risk of dementia (RR=1.0,95% CI 0.9-1.1).
These findings suggest that Parkinson's disease is an important risk factor for dementia, with a particularly high risk in young patients with Parkinson's disease.
Patients with epilepsy may bear a moderately increased risk of developing dementia.
This study does not support earlier findings in retrospective case-control studies of an increased risk of dementia in head trauma patients.
Mots-clés Pascal : Parkinson maladie, Epilepsie, Traumatisme, Crânioencéphalique, Epidémiologie, Démence, Facteur risque, Vieillard, Homme, Etude longitudinale, Pays Bas, Europe, Age, Sexe, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Extrapyramidal syndrome, Maladie dégénérative
Mots-clés Pascal anglais : Parkinson disease, Epilepsy, Trauma, Craniocerebral, Epidemiology, Dementia, Risk factor, Elderly, Human, Follow up study, Netherlands, Europe, Age, Sex, Nervous system diseases, Central nervous system disease, Cerebral disorder, Extrapyramidal syndrome, Degenerative disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0070746
Code Inist : 002B17G. Création : 199608.