Effect of apolipoprotein E genotype on Alzheimer's disease neuropathology in a cohort of elderly Norwegians.
A cohort of elderly Norwegians dying in nursing homes in the Oslo region have been genotyped for the Apolipoprotein E (ApoE) gene.
Alzheimer's disease (AD) cortical neuropathology and clinical evidence of dementia were used to assign cases without evidence of other confounding neuropathology.
Senile plaque (SP) and neurofibrillary tangle (NFT) densities in frontal, temporal and parietal cortex were then correlated with ApoE genotype to determine any relationship between ApoE genotype and AD pathology.
Comparisons with ApoE E3, E4 and E2 allele dosage failed to show any significant effect on cortical SP densities in any cortical area.
NFT densities were increased by E4 allele dosage in the frontal cortex but not in other cortical regions.
A reduction was seen in cortical NFT densities with E2 allele, though again this was not consistently significant in any of the groups.
The E3 allele failed to show any consistent effect on cortical NFT densities.
Assessment by individual genotypes showed epsilon2/3
By genotype, SP densities were generally of the order epsilon2/4
Duration of disease showed no consistent effect on neuropathological burden.
ApoE genotype may have an effect on determining whether individuals suffer from AD and the age at onset of disease but may only h...
Mots-clés Pascal : Apolipoprotéine E, Génotype, Neuropathie, Exploration, Plaque sénile, Structure neurofibrillaire, Norvège, Europe, Démence Alzheimer, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative, Homme
Mots-clés Pascal anglais : Apolipoprotein E, Genotype, Neuropathy, Exploration, Senile plate, Neurofibrillary tangle, Norway, Europe, Alzheimer disease, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease, Human
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0068663
Code Inist : 002B17G. Création : 199608.