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  1. The relation of smoking, alcohol use and obesity to risk of sigmoid colon and rectal adenomas.

    Article - En anglais

    We conducted a case-control study, using 429 cases with histologically confirmed sigmoid adenoma, 75 cases with rectal adenoma, and 3101 controls showing normal colonoscopy at least up to 60 cm from the anus.

    The subjects were male Self-Defense Forces personnel aged 48-56 who received a retirement health examination including a routine sigmoid-or colonoscopy.

    Lifestyle characteristics were ascertained by a self-administered questionnaire.

    Smoking in the recent past (¾10 years preceding the colonoscopy) and smoking in the remote past (>10 years before the colonoscopy) were both significantly associated with risk of sigmoid adenoma but not with rectal adenoma as a whole.

    After reciprocal adjustment for smoking in the two periods, only smoking in the recent past was associated with both sigmoid colon and rectal adenomas.

    Odds ratios (OR) of sigmoid adenoma (and 95% confidence interval) for the categories of 0,1-150,151-250 and =251 cigarette-years were 1.0 (reference), 1.9 (1.3-2.8), 2.1 (1.4-3.0) and 3.0 (1.9-4.7), respectively (P for trend<0.01), and those for rectal adenoma were 1.0 (reference), 1.2 (0.4-3.2), 3.5 (1.4-8.5) and 2.0 (0.6-6.7), respectively (P for trend=0.03).

    Alcohol use was significantly positively associated with sigmoid adenoma, and insignificantly associated with rectal adenoma.

    Body mass index was significantly positively associated with sigmoid adenoma, especially large ones.

    No such association was found for rectal adenoma.

    These fin...

    Mots-clés Pascal : Adénome, Côlon sigmoïde, Rectum, Epidémiologie, Facteur risque, Adulte, Homme, Tabagisme, Alcoolisme, Obésité, Etat nutritionnel, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Tumeur bénigne, Trouble nutrition

    Mots-clés Pascal anglais : Adenoma, Pelvic colon, Rectum, Epidemiology, Risk factor, Adult, Human, Tobacco smoking, Alcoholism, Obesity, Nutritional status, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Benign neoplasm, Nutrition disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0068649

    Code Inist : 002B13B01. Création : 199608.