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  1. Fulltext. Epidemiologic evidence of a role of carotenoids in cardiovascular disease prevention.

    Article, Communication - En anglais


    Antioxidant vitamins andbêta-carotene in disease prevention. Symposium. Berlin DEU, 1994/10/10.

    The tremendous chemical potential of the highly conjugated double bonds in carotenoids has driven research into their protective role in cardiovascular disease development.

    Prevention of low-density-lipoprotein oxidation and reduction of oxidative stress at the plaque formation are popular hypotheses underlying this research.

    Many epidemiologic studies have examined relations between bêta-carotene exposure and cardiovascular disease risk.

    These studies used different measures to determine carotenoid exposure : semiquantitative food-frequency questionnaires, carotenoid concentrations in serum taken before the onset of disease and analyzed after diagnosis, and carotenoid concentrations in adipose tissue.

    Although the epidemiologic evidence is consistent with a protective association between bêta-carotene and cardiovascular disease, findings from the first single intervention trial conducted in a large free-living population cast doubts on the utility of bêta-carotene for all high-risk populations. bêta-Carotene may only represent a marker of dietary behavior conducive to lower risk of cardiovascular disease.

    Research on other carotenoids is needed.

    Mots-clés Pascal : Congrès, Article synthèse, Epidémiologie, Alimentation, Facteur risque, Prévention, bêta-Carotène, Caroténoïde, Appareil circulatoire pathologie, Antioxydant, Homme

    Mots-clés Pascal anglais : Congress, Review, Epidemiology, Feeding, Risk factor, Prevention, Carotenoid, Cardiovascular disease, Antioxidant, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0065701

    Code Inist : 002B02N. Création : 199608.