Antioxidant vitamins andbêta-carotene in disease prevention. Symposium. Berlin DEU, 1994/10/10.
The tremendous chemical potential of the highly conjugated double bonds in carotenoids has driven research into their protective role in cardiovascular disease development.
Prevention of low-density-lipoprotein oxidation and reduction of oxidative stress at the plaque formation are popular hypotheses underlying this research.
Many epidemiologic studies have examined relations between bêta-carotene exposure and cardiovascular disease risk.
These studies used different measures to determine carotenoid exposure : semiquantitative food-frequency questionnaires, carotenoid concentrations in serum taken before the onset of disease and analyzed after diagnosis, and carotenoid concentrations in adipose tissue.
Although the epidemiologic evidence is consistent with a protective association between bêta-carotene and cardiovascular disease, findings from the first single intervention trial conducted in a large free-living population cast doubts on the utility of bêta-carotene for all high-risk populations. bêta-Carotene may only represent a marker of dietary behavior conducive to lower risk of cardiovascular disease.
Research on other carotenoids is needed.
Mots-clés Pascal : Congrès, Article synthèse, Epidémiologie, Alimentation, Facteur risque, Prévention, bêta-Carotène, Caroténoïde, Appareil circulatoire pathologie, Antioxydant, Homme
Mots-clés Pascal anglais : Congress, Review, Epidemiology, Feeding, Risk factor, Prevention, Carotenoid, Cardiovascular disease, Antioxidant, Human
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Cote : 96-0065701
Code Inist : 002B02N. Création : 199608.