Antioxidant vitamins andbêta-carotene in disease prevention. Symposium. Berlin DEU, 1994/10/10.
Ecologic studies of vitamin E have shown that regions with relatively low dietary vitamin E tend to have higher rates of coronary heart disease (CHD), but it is difficult to adjust for other risk factors.
Cross-sectional studies in individuals have yielded conflicting results, as have prospective studies based on stored blood samples.
Two large prospective studies found that persons who had used vitamin E supplements for =2 y had 40% lower rates of CHD.
Short durations and doses of<100 IU/d had no significant effect.
The effect of dietary vitamin E was modest and nonsignificant.
Adjustment for a wide array of other coronary risk factors had little effect on the findings, which were specific for vitamin E and not other supplements.
The only large, randomized trial found no material reduction in CHD risk for 50 IU vitamin E/d. The epidemiologic evidence suggests that high doses of vitamin E may reduce the risk of CHD.
Mots-clés Pascal : Congrès, Article synthèse, Epidémiologie, Alimentation, Facteur risque, Prévention, alpha-Tocophérol, Relation dose réponse, Cardiopathie coronaire, Infarctus, Myocarde, Vitamine, Antioxydant, Appareil circulatoire pathologie, Homme
Mots-clés Pascal anglais : Congress, Review, Epidemiology, Feeding, Risk factor, Prevention, alpha-Tocopherol, Dose activity relation, Coronary heart disease, Infarct, Myocardium, Vitamin, Antioxidant, Cardiovascular disease, Human
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