To evaluate a potential causal relationship between asbestos exposure and the risk of colorectal cancer, 30 cohort studies published in English were reviewed and analyzed.
The latest report of each cohort up through 1993 was used.
The outcome measure was the standardized morbidity (incidence) or mortality ratio (SMR).
Summary SMRs were examined by type of cohort registration, type of work, type of asbestos, latency from onset of exposure to period of risk, and incidence only.
The overall relative risk was 0.99 for all 30 studies.
The evidence does not meet the important criteria for a judgment of causality because the relative risk is not consistently elevated, weak in the two studies with a statistically significant elevation of SMR, and limited data do not support a dose-response relationship.
Mots-clés Pascal : Amiante, Carcinogène, Toxicité, Tumeur maligne, Côlon, Rectum, Homme, Exposition professionnelle, Article synthèse, Etude cohorte, Epidémiologie, Médecine travail, Côlon pathologie, Rectum pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Asbestos, Carcinogen, Toxicity, Malignant tumor, Colon, Rectum, Human, Occupational exposure, Review, Cohort study, Epidemiology, Occupational medicine, Colonic disease, Rectal disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0065533
Code Inist : 002B03L03. Création : 199608.