We assessed health risks to nurses and therapists exposed occupationally to ribavirin aerosol, a known rodent teratogen, by measuring uptake as a function of exposure concentration.
During a 4-d period, healthy, nonsmoking, young adult volunteers (N=14) were exposed 4 h/d to respirable ribavirin aerosol at concentrations that exceeded occupational levels.
Intermittent exercise occurred during exposure, and all activities occurred in a simulated hospital room.
Ribavirin was assayed in plasma, red cells, and urine ; lung function and symptoms were also measured.
In 7 volunteers who were exposed to 30 mg/m3 (i.e., received=10% of therapeutic dose), postexposure ribavirin concentrations in plasma and urine were similar on all 4 d, averaging 0.89 mumol/l and 131 mumol/l, respectively.
These concentrations decreased after exposure, with half-times of 37-39 h. Red-cell concentrations averaged 31 mumol/l on d 4, accounting for<5% of inhaled ribavirin mass, and they remained stable for 4 d afterward.
In 7 volunteers exposed to 3 mg/m3 (i.e., 1% of therapeutic dose), plasma averaged 0.075 mumol/l and red cells averaged 3 mumol/l on d 4 (i.e., near detection limits).
Small variations occurred in lung function, reported symptoms, and hematologic values for exposures to both 3 and 30 mug/m3 ; therefore, these effects were most likely not caused by ribavirin.
Typical occupational exposures to ribavirin, without recommended protective measures, should result in undetecta...
Mots-clés Pascal : Personnel sanitaire, Infirmier, Médecin, Ribavirine, Antiviral, Aérosol, Tératogène, Homme, Volontaire, Pharmacocinétique, Inhalation, Toxicité
Mots-clés Pascal anglais : Health staff, Nurse, Physician, Antiviral, Aerosols, Teratogen, Human, Volunteer, Pharmacokinetics, Inhalation, Toxicity
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0064801
Code Inist : 002B30A05. Création : 199608.