logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Computerised record linkage : compared with traditional patient follow-up methods in clinical trials and illustrated in a prospective epidemiological study.

    Article - En anglais

    Computerised record linkage systems have great potential for enhancing or even replacing traditional methods of adverse event reporting based on active patient follow-up, both in clinical trials and in epidemiological studies.

    The West of Scotland Coronary Prevention Study (WOSCOPS) is a randomised double-blind clinical trial of pravastatin versus placebo in the primary prevention of coronary heart disease, with coronary heart disease death plus nonfatal myocardial infarction as its primary end point.

    Adverse event reporting is based on active patient follow-up at routine trial visits.

    In parallel with this approach, we have obtained computer records of all deaths, incident cancers, and hospitalisations for our subjects by linking their names, dates of birth, and postcodes of their home addresses with a Scottish national database operated by the Scottish Record Linkage system.

    The results of this comparative study, based on follow-up of the 6595 men ages 45-64 randomised in WOSCOPS, demonstrate minor flaws in both systems, show that follow-up based on computerised linkage alone can be as effective as reporting based on direct contact with the patients, and show that a system based on both approaches provides a direct cross-validation of the two approaches to adverse event reporting while minimising the frequency of unreported events.

    Mots-clés Pascal : Pravastatine, Prévention, Chimiothérapie, Cardiopathie coronaire, Complication, Essai clinique, Epidémiologie, Informatique, Linkage, Information, Enregistrement, Surveillance, Etude longitudinale, Base donnée, Méthodologie, Appareil circulatoire pathologie

    Mots-clés Pascal anglais : Prevention, Chemotherapy, Coronary heart disease, Complication, Clinical trial, Epidemiology, Computer science, Linkage, Information, Recording, Surveillance, Follow up study, Database, Methodology, Cardiovascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0056406

    Code Inist : 002B30A08. Création : 199608.