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  1. The value of screening tests in the detection of prostate cancer. II : Retrospective analysis of free/total prostate-specific analysis ratio, age-specific reference ranges, and PSA density.

    Article - En anglais


    The ratio between free and total prostate-specific antigen (PSA) in serum (F/T ratio) was shown to improve the specificity of total serum PSA for the detection of prostate carcinoma in selected populations.

    In this study, the value of the F/T ratio for screening of prostate cancer was compared with that of age-specific reference ranges for PSA and PSA density (PSAD) by a simulation experiment.


    In 1726 men between 55 and 76 years old, 67 prostate carcinomas were detected by application of digital rectal examination (DRE), transrectal ultrasonography (TRUS), and total serum PSA.

    A serum PSA of 4.0 ng/mL or more, an abnormal DRE, or an abnormal TRUS were the indications to perform 308 biopsies.

    A simulation was performed in which an F/T ratio of 0.20 (ProStatus PSA Free/Total), age-specific PSA reference ranges, and a PSAD of 0.12 ng/mL/cc were used to study their capability to increase the specificity of total serum PSA in predicting prostate biopsy results.

    Mots-clés Pascal : Adénocarcinome, Prostate, Antigène spécifique prostate, Pays Bas, Europe, Exploration, Dépistage, Homme, Mâle, Age, Tumeur maligne, Appareil urinaire pathologie, Appareil génital mâle pathologie, Prostate pathologie

    Mots-clés Pascal anglais : Adenocarcinoma, Prostate, Prostate specific antigen, Netherlands, Europe, Exploration, Medical screening, Human, Male, Age, Malignant tumor, Urinary system disease, Male genital diseases, Prostate disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0052702

    Code Inist : 002B14D02. Création : 199608.