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  1. The value of screening tests in the detection of prostate cancer. II : Retrospective analysis of free/total prostate-specific analysis ratio, age-specific reference ranges, and PSA density.

    Article - En anglais

    Objectives

    The ratio between free and total prostate-specific antigen (PSA) in serum (F/T ratio) was shown to improve the specificity of total serum PSA for the detection of prostate carcinoma in selected populations.

    In this study, the value of the F/T ratio for screening of prostate cancer was compared with that of age-specific reference ranges for PSA and PSA density (PSAD) by a simulation experiment.

    Methods

    In 1726 men between 55 and 76 years old, 67 prostate carcinomas were detected by application of digital rectal examination (DRE), transrectal ultrasonography (TRUS), and total serum PSA.

    A serum PSA of 4.0 ng/mL or more, an abnormal DRE, or an abnormal TRUS were the indications to perform 308 biopsies.

    A simulation was performed in which an F/T ratio of 0.20 (ProStatus PSA Free/Total), age-specific PSA reference ranges, and a PSAD of 0.12 ng/mL/cc were used to study their capability to increase the specificity of total serum PSA in predicting prostate biopsy results.

    Mots-clés Pascal : Adénocarcinome, Prostate, Antigène spécifique prostate, Pays Bas, Europe, Exploration, Dépistage, Homme, Mâle, Age, Tumeur maligne, Appareil urinaire pathologie, Appareil génital mâle pathologie, Prostate pathologie

    Mots-clés Pascal anglais : Adenocarcinoma, Prostate, Prostate specific antigen, Netherlands, Europe, Exploration, Medical screening, Human, Male, Age, Malignant tumor, Urinary system disease, Male genital diseases, Prostate disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0052702

    Code Inist : 002B14D02. Création : 199608.