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  1. Comparative evaluation of orally active antibiotics against community-acquired pathogens : results of eight European countries.

    Article - En anglais

    In this multicenter study conducted in eight European countries, 13,173 pathogens - all isolated from community-acquired infections in 1992 and 1993 - were evaluated for their susceptibility to the following orally active antibiotics : penicillin G, ampicillin, amoxycillin plus clavulanic acid, cefador, cefuroxime, cefetamet, doxycycline and erythromycin.

    Ten centers in Italy, five in Germany, in the Netherlands and Switzerland, four in Greece and Spain, three in Hungary and one in Finland contributed to this study ; ready-to-use standardized microtiter panels (Sceptor system, BBL, Heidelberg, Germany) were used throughout all assays.

    The most frequently encountered species were :

    • Escherichia coli,

    • Proteus mirabilis,

    • Klebsiella pneumoniae and non-typhoid Salmonella spp.,

    • Enterobacter cloacae,

    • Streptococcus agalactiae,

    • Haemophilus influenzae,

    • Citrobacter freundii,

    • Staphylococcus pyogenes,

    • Streptococcus pneumoniae,

    • Proteus vulgaris,

    • Moraxella catarrhalis and Shigella spp.

    The percentage of susceptible isolates was assessed for each of the above-mentioned countries and European-wide with all the data available.

    The penicillin compounds exhibited the greatest activity against Gram-positive pathogens, whereas cefetamet was the most active agent against Gram-negative pathogens with a well-balanced spectrum of activity.

    Mots-clés Pascal : Benzylpénicilline, Ampicilline, Amoxicilline, Céfaclor, Céfuroxime, Doxycycline, Erythromycine, Céfétamet, Antibiotique, Antibactérien, Sensibilité résistance, Association médicamenteuse, In vitro, Isolat clinique, Etude multicentrique, Europe, Pénicilline dérivé, Céphalosporine dérivé, Tétracycline dérivé, Epidémiologie, Infection communautaire

    Mots-clés Pascal anglais : Erythromycin, Antibiotic, Antibacterial agent, Sensitivity resistance, Drug combination, In vitro, Clinical isolate, Multicenter study, Europe, Penicillin derivatives, Cephalosporin derivatives, Tetracycline derivatives, Epidemiology, Community-acquired infection

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0047038

    Code Inist : 002B02S02. Création : 01/03/1996.