Assessment of biochemical markers of bone metabolism in relation to the occurrence of fracture : a retrospective and prospective population-based study of women.
We have in a population-based setting evaluated biochemical markers of bone metabolism in 328 women, aged 40-80 years, and related it to contents of bone mineral measurements and the retrospective and prospective presence of fracture.
The participants were recruited from the city population files.
Serum samples for analysis of osteocalcin (Oc), procollagen I carboxy-terminal extension peptide (PICP), and carboxy-terminal telopeptide of type I collagen (ICTP) were taken, and forearm bone mineral content (BMC) was measured by single photon absorptiometry (SPA).
Fracture history was recorded, and the information was verified and supplemented from both radiologic and orthopedic files.
Five years later the registration of fractures was repeated.
At the initial investigation, Oc was 23% lower in women who had sustained a fracture (n=37) within 6 years before measurement (6.3 ± 3.6 mug/l vs 8.2 ± 4.2 mug/l (p=0.006)), after adjusting for age and BMC differences.
PICP and ICTP were not different from values in the women without fracture.
However, in women aged 70-80 years with a fracture sustained during the previous 6 years, PICP was lower (128 ± 32 mug/l vs 144 ± 34 mug/l, p=0.046).
Oc and ICTP were significantly correlated to age and BMC (Oc-age r=0.36, Oc-BMC r=-0.31, ICTP-age r=0.44, ICTP-BMC r=-0.24).
The correlations of PICP were weaker.
Mots-clés Pascal : Marqueur biologique, Os, Métabolisme, Epidémiologie, Etiologie, Turnover, Fracture, Système ostéoarticulaire, Système ostéoarticulaire pathologie, Traumatisme, Homme, Femelle
Mots-clés Pascal anglais : Biological marker, Bone, Metabolism, Epidemiology, Etiology, Turnover, Fracture, Osteoarticular system, Diseases of the osteoarticular system, Trauma, Human, Female
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0042835
Code Inist : 002B15A. Création : 01/03/1996.