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  1. Postlicensure surveillance for Haemophilus influenzae type b invasive disease after use of Haemophilus influenzae type b oligosaccharide CRM197 conjugate vaccine in a large defined United States population : a four-year eight-month follow-up.

    Article - En anglais

    Haemophilus influenzae type b (Hib) oligosaccharide CRM197 (HbOC-HibTITER, Lederle-Praxis) conjugate vaccine was approved for use in infants in October, 1990, as a result of an evaluation of 61 080 infants in whom the vaccine was found to be safe and effective.

    This report details a 4-year 8-month period of surveillance after the licensure of this vaccine in the large defined United States population from which these children were drawn.

    The population analyzed consisted of approximately 240000 children from 0 through 8 years of age in a total health plan population of 2 500 000.

    During this period 16 cases of invasive Hib disease were identified.

    Nine had not received any type of Hib vaccine, 2 had received the unconjugated polysaccharide Hib vaccine and 4 had received the HbOC vaccine.

    The 16th case occurred on July 10,1994, in a 7-year-old child who at 18 months of age had received a single dose of PRP-D (ProHIBIT ; Connaught) conjugate Hib vaccine.

    The use of HbOC conjugate Hib vaccine in this population has coincided with the virtual disappearance of invasive Hib disease in children 0 through 8 years of age with no cases of invasive Hib disease occurring in the past 3 years and 4 months after the use of this vaccine.

    During this period no concomitant increase of H. influenzae disease with other types of H. influenzae organisms has been seen in the study population.

    Mots-clés Pascal : Epidémiologie, Prévention, Enfant, Homme, Immunoprotection, Incidence, Bactériose, Infection, Vaccination, Haemophilus influenzae, Pasteurellaceae, Bactérie, Californie, Etats Unis, Amérique du Nord, Amérique

    Mots-clés Pascal anglais : Epidemiology, Prevention, Child, Human, Immunoprotection, Incidence, Bacteriosis, Infection, Vaccination, Haemophilus influenzae, Pasteurellaceae, Bacteria, California, United States, North America, America

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0042009

    Code Inist : 002B05A02. Création : 01/03/1996.