A prospective cohort study on the mother-to-child transmission of human immunodeficiency virus type 1 (HIV1), type 2 (HIV2) and dual positivity (HIV1+HIV2) was carried out in Banfora, West Burkina Faso.
The study samples consist of 117 newborns of HIV-seropositive women matched to 234 newborns of HIV-seronegative women.
Among cases, 91 were born of HIV1-seropositive mothers, 15 were born of HIV2-seropositive mothers and 11 were born of HIV1 and HIV2 dual-seropositive mothers and were included in an 18-month follow-up.
Calculation of the mother-to-child transmission rate was according to the recommendations of the European Economic Community working group.
The HIV1 mother-to-child transmission rate was estimated to be 27.8% (95% confidence interval (CI) 24.5 to 32.4) with one method and 25.5% (95% CI 13.5 to 37.5) with a second method.
For HIV2, this rate was estimated to be 29.5% (95% CI 26.0 to 39.8) and was not statistically different from the HIV1 mother-to-child transmission rate.
No case of transmission was observed in children born of dual seropositive mothers.
Survival rate at month 18 was significantly lower for children born of HIV1 mothers : 83.7% (95% CI 78.2 to 92.2).
Survival rates were similar between children born of HIV2-seropositive (86.7), dual HIV1+2-positive (100) and seronegative mothers.
Findings suggest a higher mother-to-child transmission rate of HIV2 in children born in Burkina Faso than in Europe and a low clinical expression of HIV2 in children.
Mots-clés Pascal : Immunodéficit, SIDA, Virose, Infection, Immunopathologie, Epidémiologie, Nouveau né, Homme, Nourrisson, Burkina Faso, Afrique, Transmission mère enfant, Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Virus HIV2, Etude cohorte
Mots-clés Pascal anglais : Immune deficiency, AIDS, Viral disease, Infection, Immunopathology, Epidemiology, Newborn, Human, Infant, Burkina Faso, Africa, Mother to child transmission, HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, HIV-2 virus, Cohort study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0042002
Code Inist : 002B06D01. Création : 01/03/1996.