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  1. Programme for preventing perinatal hepatitis B infection through screening of pregnant women and immunisation of infants of infected mothers in the Netherlands, 1989-92.

    Article - En anglais

    Abtract Objectives-To launch a programme for the prevention of perinatal infection with hepatitis B in the Netherlands.

    Design-Routine antenatal screening and intervention programme.

    Setting-Community antenatal programme, the Netherlands.

    Subjects-Infants of mothers who were carriers of hepatitis B detected by routine screening.

    Interventions-Infants of infected mothers received hepatitis B immunoglobulin at birth and four doses of hepatitis B vaccine in conjunction with routine immunisation at 3,4,5, and 11 months of age.

    Main outcome measures-Results of screening and immunisation from 1989-92.


    The coverage of screening increased from 46% in 1989 to 84% in 1992.

    Hepatitis B surface antigen was detected in 2145 women (0.44%). There was considerable variation in the timing of vaccination ; 17% (258) of the infants received their first dose more than two weeks late.

    Of the 59% (583) of infants who received the fourth dose more than two weeks beyond target age, 14% (141) also received their first dose too late.

    Conclusions-A prevention programme for perinatal hepatitis B in an area of low prevalence, when incorporated into existing health care, is feasible and achieves satisfactory coverage rates.

    Intensive follow up is needed to improve adherence to the immunisation schedule.

    Mots-clés Pascal : Dépistage, Prévention, Homme, Nouveau né, Adulte, Hépatite virale B, Gestation, Immunoprotection, Immunoglobuline, Royaume Uni, Appareil digestif pathologie, Foie pathologie, Infection, Virose, Gestation pathologie, Nouveau né pathologie, Europe

    Mots-clés Pascal anglais : Medical screening, Prevention, Human, Newborn, Adult, Viral hepatitis B, Pregnancy, Immunoprotection, Immunoglobulins, United Kingdom, Digestive diseases, Hepatic disease, Infection, Viral disease, Pregnancy disorders, Newborn diseases, Europe

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0041074

    Code Inist : 002B30A03B. Création : 01/03/1996.