Abtract Objectives-To launch a programme for the prevention of perinatal infection with hepatitis B in the Netherlands.
Design-Routine antenatal screening and intervention programme.
Setting-Community antenatal programme, the Netherlands.
Subjects-Infants of mothers who were carriers of hepatitis B detected by routine screening.
Interventions-Infants of infected mothers received hepatitis B immunoglobulin at birth and four doses of hepatitis B vaccine in conjunction with routine immunisation at 3,4,5, and 11 months of age.
Main outcome measures-Results of screening and immunisation from 1989-92.
The coverage of screening increased from 46% in 1989 to 84% in 1992.
Hepatitis B surface antigen was detected in 2145 women (0.44%). There was considerable variation in the timing of vaccination ; 17% (258) of the infants received their first dose more than two weeks late.
Of the 59% (583) of infants who received the fourth dose more than two weeks beyond target age, 14% (141) also received their first dose too late.
Conclusions-A prevention programme for perinatal hepatitis B in an area of low prevalence, when incorporated into existing health care, is feasible and achieves satisfactory coverage rates.
Intensive follow up is needed to improve adherence to the immunisation schedule.
Mots-clés Pascal : Dépistage, Prévention, Homme, Nouveau né, Adulte, Hépatite virale B, Gestation, Immunoprotection, Immunoglobuline, Royaume Uni, Appareil digestif pathologie, Foie pathologie, Infection, Virose, Gestation pathologie, Nouveau né pathologie, Europe
Mots-clés Pascal anglais : Medical screening, Prevention, Human, Newborn, Adult, Viral hepatitis B, Pregnancy, Immunoprotection, Immunoglobulins, United Kingdom, Digestive diseases, Hepatic disease, Infection, Viral disease, Pregnancy disorders, Newborn diseases, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0041074
Code Inist : 002B30A03B. Création : 01/03/1996.