To understand the development of cadmium (Cd) - induced renal tubular dysfunction, cross-sectional assessment of renal function in the inhabitants of the Cd-polluted Jinzu River basin in Toyama, Japan, was carried out.
Sixty-seven men and 78 women, aged 56 to 71 years whose urinary bêta2-microglobulin (bêta2-m) exceeded 1,000 mug/g creatinine, were examined and divided into five groups according to their values of fractional excretion of bêta2-m (FEbêta2-m).
Comparisons were made between six groups including the inhabitants of a non-polluted area as a reference group.
Significantly increased values of fractional excretion of urate (FEUA), calcium (FECa), sodium (FENa), and chloride (FECl), serum creatinine and bêta2-m, and urinary protein were detected even in the subjects with FEbêta2-m level below 1 percent compared with the reference group.
Fractional phosphate reabsorption (percent TRP) was significantly decreased in the subjects with FEbêta2-m level above 10 percent.
Creatinine clearance (CCr) decreased with increase in FEbêta2-m, and the subjects with FEbêta2-m above 30 percent showed significantly decreased CCr values compared to those with FEbêta2-m below 30 percent.
In summary, FEUA, FECa, FENa, and FECl, as well as low-molecular-weight proteins such as bêta2-m, are increased in the early stage of Cd-induced renal tubular dysfunction.
Mots-clés Pascal : Néphropathie, Analyse, Fonction rénale, Pollution, Environnement, Cadmium, Facteur risque, Homme, Japon, Asie, Appareil urinaire pathologie, Rein pathologie
Mots-clés Pascal anglais : Nephropathy, Analysis, Renal function, Pollution, Environment, Cadmium, Risk factor, Human, Japan, Asia, Urinary system disease, Renal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0037323
Code Inist : 002B03M03. Création : 01/03/1996.