Absence of an association of rheumatoid arthritis and diffuse idiopathic skeletal hyperostosis : a case-control study.
To compare the frequency of diffuse idiopathic skeletal hyperostosis (DISH), based on an evaluation of chest radiographs, in 2 populations of patients : those with and without rheumatoid arthritis (RA).
Cases of RA were obtained from the Wichita Arthritis Center databank and controls from a private cardiology practice.
Analyses were conducted to take into account the sensitivity and specificity of chest radiographs for the diagnosis of DISH.
Among 748 radiographs (357 RA and 391 controls), 29 were diagnosed as DISH (21 controls and 8 RA).
The mean age for the RA group was 66.2 yrs (SD=11.9) and 108 (30.2%) were men.
Control subjects had a mean age of 69.6 yrs (SD=11.4) and 138 (35.4%) were men.
The DISH patients, compared with those without DISH, were more likely to be male (p=0.004) and older (p<0.001).
After accounting for age and sex, the relative risk of DISH in RA versus the controls was 0.40 (95% confidence interval : 0.20 to 1.01).
After taking into account the sensitivity and specificity in this population, the adjusted prevalence of DISH for the RA group was 1% (95% confidence interval : 0.1 to 3.7) and 3.1% (95% confidence interval : 0.2 to 7.9) for the control group.
We confirmed the increase in frequency of DISH with increasing age and male sex, but failed to support an increased association of DISH with RA.
Mots-clés Pascal : Ossification, Polyarthrite rhumatoïde, Chronique, Maladie autoimmune, Rachis pathologie, Rhumatisme inflammatoire, Immunopathologie, Système ostéoarticulaire pathologie, Association, Epidémiologie, Homme, Hétérotopique, Maladie dégénérative, Hyperostose ankylosante vertébrale, Etude cas témoin
Mots-clés Pascal anglais : Ossification, Rheumatoid arthritis, Chronic, Autoimmune disease, Spine disease, Inflammatory joint disease, Immunopathology, Diseases of the osteoarticular system, Association, Epidemiology, Human, Heterotopic, Degenerative disease, Ankylosing hyperostosis, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0027520
Code Inist : 002B15D. Création : 01/03/1996.